Amyloidosis is a rare and often misdiagnosed health condition characterized by the build-up of abnormal proteins called amyloids in various organs and tissues in the body. A few organs at risk include the heart, spleen, kidneys, liver, digestive tract, and nervous system. Detecting this condition early is crucial for effective management of symptoms. Here are early warning signs of amyloidosis to help one identify them and seek an early diagnosis:

Fatigue and weakness
One of the earliest signs of amyloidosis is unexplained fatigue and weakness. So, those affected often experience a persistent lack of energy, which might be attributed to the accumulation of amyloids interfering with normal organ and tissue function. This fatigue, unlike general tiredness, may not improve with rest.

Loss of appetite
Amyloidosis may affect the digestive system, leading to poor nutrient absorption and reduced appetite. Any such changes should prompt further investigation by a healthcare professional.

Shortness of breath
Shortness of breath, either while engaging in physical activities or while lying down, can be a sign of amyloidosis. The accumulation of amyloids in the heart may restrict its ability to pump blood efficiently, leading to difficulty breathing.

Swelling in the ankles and legs
Swelling, particularly in the ankles and legs, might be another early symptom, as amyloidosis can interfere with the body’s ability to regulate fluid balance. Swelling in these areas, especially if it appears suddenly or is accompanied by other symptoms, should be a cause for concern.

Nerve damage
Nerve damage, or neuropathy, can be a sign of amyloidosis. The damage could manifest as tingling or numbness in the extremities, such as the hands and feet. This sign could worsen over time, affecting motor function and causing muscle weakness.

Changes in skin color and texture
Sudden changes in their skin color and texture could also be early warning signs of amyloidosis. Sometimes, one may notice waxy patches with a purple hue, which may be accompanied by bruising or small red or purple dots on the skin.